These patients had neither pituitary surgery nor radiotherapy within the follow-up period. Wilcoxon matched-pairs signed-rank test was used to compare evolutive changes (before-after) of hormone levels in the same patients (PSPA-nt and PA-nt groups). Continuous variables, like hormone levels, age, and BMI, were submitted to the Anderson‒Darling normality test; because they were assessed as nonnormally distributed, nonparametric tests were conducted for all statistical analyses. The level of gonadal hormone levels 3 months after surgery were compared with levels before surgery, as shown in Table 4. Out of 291 patients, preoperative testosterone was normal in 164 patients (56.36%) and was lower than normal in 127 patients (43.64%). All patients underwent sex hormone testing and magnetic resonance imaging (MRI) at our center before surgery. Fifteen patients had coagulative necrotic pituitary apoplexy (CNPA) and all of them chose early surgery. According to the above criteria, a total of 291 male patients with NFPA were enrolled. This study analyzed male patients with NFPA who underwent trans-sphenoidal surgery at the Department of Neurosurgery, Tongji Hospital, from June 2019 to December 2021. The rise of trans-sphenoidal extra-pseudocapsule resection not only improves the resection rate of surgery, but also plays an important role in preserving pituitary function4,8,10. In women, correlations may exist between positive orgasm experience and testosterone levels. Regular monitoring during treatment typically includes hematocrit levels every 3-6 months to prevent polycythemia, along with PSA monitoring in men over 40. Current clinical guidelines recommend comprehensive baseline evaluation including complete blood count, lipid panel, prostate-specific antigen, and cardiovascular risk assessment before initiating testosterone replacement therapy. Testosterone treatment for reasons other than possible improvement of sexual dysfunction may not be recommended. Common side effects from testosterone medication include acne, swelling, and breast enlargement in males. Testosterone is used as a medication for the treatment of male hypogonadism, gender dysphoria, and certain types of breast cancer. However, if the pituitary hormone levels are within normal ranges, it’s not a cause for concern. Hyperpituitarism happens when your pituitary gland makes too much of one or more hormones. Treatment of hypopituitarism involves replacing the lacking hormones and monitoring the levels through blood tests. Hypopituitarism is a condition in which there’s a lack of one, multiple or all of the hormones your pituitary gland makes. There are several different types of functioning pituitary adenomas based on which hormone they release. The anterior pituitary lobe is bigger than the posterior lobe and accounts for about 80% of the total weight of your pituitary gland. Your hypothalamus also creates oxytocin and antidiuretic hormone and tells your posterior pituitary when to store and release these hormones. Patients with CNPA have some characteristic imaging findings, particularly after enhanced scans. Gonadal hormone testing was performed between 8 and 10 am. We explored the predictors affecting postoperative testosterone recovery using logistics regression analysis.
