Table 2 shows adverse reactions reported by ≥3% of patients who received Natesto three times daily in both the 90-day clinical study and in the 90-day extension period. Table 1 shows adverse reactions reported by ≥3% of patients treated with 11 mg three times daily in the 90-day clinical study. TNG has up to 12 hours of trough time at or below patients’ baseline (i.e., below the normal range), which is likely a factor in limiting unwanted anabolic effects on hematocrit .Limitations of the study are that the numbers of patients with very low endogenous TT levels were small. It is a nasal gel that is applied inside the nose. Patients are responsible for reporting receipt of this coupon benefit to any insurer, health plan, or other third party who pays for or reimburses any part of the prescription filled using the coupon, as may be required by payer or plan rules or in accordance with any state or federal law. On each valid Natesto prescription or refill, the Natesto Savings Card benefit may be applied to dispensed quantities of no less than 20 days (2 dispensers) to no more than 90 days (9 dispensers) per prescription dispensed. Once a patient exceeds the $3500 annual benefit in the plan, the patient is responsible for all remaining copay or cost-sharing obligations throughout the conclusion of the current benefit year. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the US. Some nasal sprays should not be used with Natesto. If you have any questions, talk to your health care provider. If you become pregnant, contact your health care provider right away. Call your health care provider if your blood pressure increases while using this medicine. This may increase your risk of a heart attack or stroke over time. You may be at a higher risk of sleep apnea if you have obesity or lung problems, such as asthma or chronic obstructive pulmonary disease (COPD).